Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review

BPC-157, a pentadecapeptide derived from human gastric juice, has emerged as one of the most studied peptides in sports medicine and orthopaedic research. This systematic review by Vasireddi, Hahamyan, Salata, and colleagues, published in HSS Journal, rigorously evaluated the available evidence on BPC-157's applications in orthopaedic sports medicine.

The authors conducted a systematic review following established methodological standards, screening and analyzing published studies on BPC-157's effects on musculoskeletal tissues. The review examined both in vitro and in vivo studies to assess the quality and consistency of evidence supporting its therapeutic use.

The findings consistently supported BPC-157's tissue-healing and anti-inflammatory capabilities across multiple study models. The peptide demonstrated positive effects on tendon repair, ligament healing, muscle recovery, and inflammation reduction, with a favorable safety profile observed across the reviewed studies.

For athletes and active individuals dealing with sports injuries, this systematic review provides encouraging evidence that BPC-157 may offer meaningful benefits for recovery. The consistency of positive results across different tissue types and injury models strengthens the case for its clinical application in sports medicine settings.